LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
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منابع مشابه
Dietary fat overload reprograms brown fat mitochondria
Chronic nutrient overload accelerates the onset of several aging-related diseases reducing life expectancy. Although the mechanisms by which overnutrition affects metabolic processes in many tissues are known, its role on BAT physiology is still unclear. Herein, we investigated the mitochondrial responses in BAT of female mice exposed to high fat diet (HFD) at different steps of life. Although ...
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Brown adipose tissue (BAT) combusts high amounts of fatty acids, thereby lowering plasma triglyceride levels and reducing obesity. However, the precise role of BAT in plasma cholesterol metabolism and atherosclerosis development remains unclear. Here we show that BAT activation by β3-adrenergic receptor stimulation protects from atherosclerosis in hyperlipidemic APOE*3-Leiden.CETP mice, a well-...
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The inheritance pattern of a number of major genetic disorders suggests the possible involvement of genes that are expressed from one allele and silent on the other, but such genes are difficult to detect. Since DNA methylation in regulatory regions is often a mark of gene silencing, we modified existing microarray-based assays to detect both methylated and unmethylated DNA sequences in the sam...
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A therapy for weight loss must, therefore, involve a decrease in food intake andor. Brown fat cells possess large numbers of mitochondria that contain a unique.See the article High Incidence of Metabolically Active Brown Adipose Tissue in Healthy. Risk factor for many other diseases, including type 2 diabetes, cardiovascular disease. Article PubReader ePub beta PDF 86K Citation.Purpose of revie...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2018
ISSN: 2041-1723
DOI: 10.1038/s41467-018-05933-8